{"created":"2023-05-15T10:32:25.862472+00:00","id":18,"links":{},"metadata":{"_buckets":{"deposit":"667ea8c7-82f3-45d3-80c5-ffcf0fe7a079"},"_deposit":{"created_by":12,"id":"18","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"18"},"status":"published"},"_oai":{"id":"oai:daiichi-cps.repo.nii.ac.jp:00000018","sets":["1:5"]},"author_link":["28","45","43","44"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"36","bibliographicPageStart":"23","bibliographic_titles":[{"bibliographic_title":"第一薬科大学研究年報"},{"bibliographic_title":"Annual report of Daiichi University of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Yokukansan(YKS) is one of the traditional Japanese medicines called kampo in Japan. It is composed of seven kinds of medicinal herbs, Atractylodis Lanceae Rhizoma (rhizome of Atractylodes lancea D.C., Compositae), Poria (sclerotium of Poria cocos Wolf, Polyporaceae), Cnidii Rhizoma (rhizome of Cnidium officinale Makino, Umbelliferae), Angelicae Radix (root of Angelica acutiloba Kitagawa, Umbelliferae), Bupleuri Radix (root of Bupleurum falcatum Linné, Umbelliferae), Glycyrrhizae Radix (root and stolon of Glycyrrhiza uralensis Fisher, Leguminosae), and Uncaria Uncis Cum Ramulus (hook of Uncaria rhynchophilla Miquel, Rubiaceae).\nMany studies showing the effects and mechanisms of YKS on psychosomatic and neurological symptoms have been published. As a mechanism for pharmacological of YKS was reported to attenuate abnormal glutamate release in rats on a diet deficient in zinc. Further, YKS significantly suppressed the increase in extracellular concentrations of glutamate and aspartate seen in the hippocampus of zinc deficient rats after stimulation with KCl. In addition, YKS suppressed the excitement of a nerve cell by its partial agonistic effect on 5-hydoroxytryptamine 1A receptor and by repeated treatment-induced down-regulation of 5-hydoroxytryptamine 2A receptor. As the effect on a dementia model animal, YKS　inhibited the 2, 5-dimethoxy-4-iodoamphetamine-induced head-twitch response and decreased expression of 5-hydroxytryptamine 2A receptors in the prefrontal cortex. As a clinical evidence of YKS was reported to improve behavioral and psychological symptoms of dementia (BPSD) including hallucinations, agitation, and aggressiveness in patients with Alzheimer’s disease, dementia with Lewy bodies, and other forms of senile dementia. Also,YKS attenuates neuropathic pain due to postherpetic neuralgia, complex regional pain syndrome, central cord syndrome and ameliorates neuropathic pain symptoms in patient. \nAntipsychotic drugs have been used to control behavioral symptoms, their associated adverse effects frequently impact on the activities of daily living and quality of life of treated patients. But YKS was effective for the treatment of clinical symptoms in patients without adverse effects.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"第一薬科大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00135346","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02868016","subitem_source_identifier_type":"ISSN"}]},"item_10002_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499.8","subitem_subject_scheme":"NDC"}]},"item_10002_text_25":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_text_value":"Katsumi Kido"},{"subitem_text_value":"Risa Morikawa"},{"subitem_text_value":"Yuri Toyota"},{"subitem_text_value":"Naomichi Fukuda"}]},"item_10002_text_26":{"attribute_name":"publisher","attribute_value_mlt":[{"subitem_text_value":"Daiichi University of Pharmacy"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"城戸, 克己"},{"creatorName":"キド, カツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森川, 皇沙"},{"creatorName":"モリカワ, リサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"44","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"豊田, 有里"},{"creatorName":"トヨタ, ユリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"45","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福田, 直通"},{"creatorName":"フクダ, ナオミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"28","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-02"}],"displaytype":"detail","filename":"DYnenpou29(23-36p).pdf","filesize":[{"value":"676.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"第一薬科大学研究年報29(23-36p)","url":"https://daiichi-cps.repo.nii.ac.jp/record/18/files/DYnenpou29(23-36p).pdf"},"version_id":"7b7fcf22-770c-4fd2-bf85-c273c92553b6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抑肝散の薬理作用と臨床効果についての紹介","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抑肝散の薬理作用と臨床効果についての紹介"},{"subitem_title":"Introduction of Pharmacological mechanisms and Clinical evidence of Yokukansan","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["5"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-15"},"publish_date":"2013-10-15","publish_status":"0","recid":"18","relation_version_is_last":true,"title":["抑肝散の薬理作用と臨床効果についての紹介"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-05-15T10:38:40.234081+00:00"}