Based on the “serotonin hypothesis”, the agents which could increase the serotonin transmission in the brain are thought to be effective for the palliation of depression. Present study, we investigated the effect of chronic or acute treatment with mifepristone, a glucocorticoid receptor antagonist, on the basal release of serotonin in the basolateral amygdala (BLA) in rats. The basal release of serotonin in the BLA was significantly increased after chronic treatment with mifepristone for 14 days. On the other hand, the basal release of serotonin in the BLA was not affected by acute treatment with mifepristone. These results suggest that mifepristone may have a therapeutic potential for depression by novel mechanisms.
ラット扁桃体基底外側部におけるセロトニン基礎遊離量に及ぼすグルココルチコイド受容体拮抗薬mifepristone の影響
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第一薬科大学研究年報28(1-8p)
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